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Notably, MCP-1, also known as chemokine ligand 2 (CCL2), plays a pivotal role in promoting BBB instability by facilitating the recruitment of monocytes/MΦs into CNS compartment and contributing to the reorganization of TJ and the actin cytoskeleton (Stamatovic et al., 2003)

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As pointed out by Chauhan and Chauhan, a wide range of studies “… suggest increased oxidative stress in autism that may contribute to the development of this disease.” 12 However, it is unknown whether factors causing oxidative stress have increased in Western societies concomitantly with inflammation