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HIF-1α and PFKFB3 mediate a tight relationship between proinflammatory activation and anerobic metabolism in atherosclerotic macrophages

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MeHg not only induces GSH depletion 39 but also binds to the thiol groups of at least two thioredoxin forms (Trx1 and TrxR) inhibiting their function, a proposed major molecular mechanism of mercury toxicity 38