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We showed in a rat model that a 0·5 or 1 % APAP diet, equivalent to 2 and 4 g/d for humans, respectively ( Reference Mast, Joly and Savary-Auzloux 102 ) , during 17 d led to the formation of APAP–protein adducts ( Reference Mast, Lyan and Joly 103 )

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For optimal results, research points to a combination of 2 grams L-citrulline with 2 grams L-arginine as an effective approach