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Capmatinib and Tepotinib are designed as a selective small-molecule inhibitors that indirectly prevent the activation of downstream signaling by blocking c-MET phosphorylation at the start, by binding to the ATP-binding pocket of the kinase in its active conformation [112]

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Transthoracic echocardiography was employed to measure the left ventricular end-diastolic dimension, ejection fraction, and left atrial size