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However, switching from efavirenz to etravirine seems feasible for the majority of patients because of development of resistance or toxicity to efavirenz.11,12 It is therefore important to be aware that the effect of efavirenz on CYP3A4 may last beyond discontinuation of efavirenz because of its long half-life and subtherapeutic concentrations of etravirine are at risk during the first few days after the switch