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Thus, AdCbl supplementation may result in a slower synthesis of intracellular AdCbl and MeCbl compared with MeCbl supplementation.31 The methionine produced in those cyclic methylation reactions supports production of SAMe, which acts as a methyl donor in reactions involving DNA and certain hormones or neurotransmitters.32,33 Intracellular synthesized SAMe derives its methyl component either from 5-methyl-tetrahydrofolate, with cobalamin acting as an intermediate carrier of the methyl group, or from intake of methionine, betaine, or choline