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This fragment oligomerizes and inserts into the plasma membrane, forming pores that disrupt membrane integrity, increase ion influx, and lead to cell swelling and eventual rupture (Kovacs and Miao, 2017)

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In addition to other regulatory mechanisms, such as tonic activity changes 2 , increased number of active neurons 53 and modulation at the nerve terminal level 54 , FFL motifs may thus provide a mechanism 55,56 to maintain hypothalamic circuit robustness in the face of perturbed metabolic homeostasis 57,58