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Specifically, the generation of ceramides by dihydroceramide desaturase 1 (DES1) in adipocytes seems to impart some of the lipotoxic effects such as impaired glucose utilization, insulin resistance and hepatic steatosis (198)

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Specificity of Streptococcus pyogenes NAD(+) glycohydrolase in cytolysin-mediated… [PMID: 17042787] Laboratory literature summary: Specificity of Streptococcus pyogenes NAD(+) glycohydrolase in cytolysin-mediated translocation