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With this in mind, it is clear that microbes regulate energy homeostasis in the colon, and in the absence of microbiota, autophagy is used as a mechanism to derive amino acids that can be diverted toward energy production

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For instance, in a mouse model of Parkinson’s disease, NSCs transplantation has been demonstrated to significantly alleviate vascular injury and promote the recovery of neural function ( 2.2.2 Regulatory mechanisms of hypoxia on NSCs In 1992, Reynolds and colleagues successfully isolated NSCs from the striatum of adult mice, marking a new era in NSC research ( Notably, the Notch1 signaling pathway is significantly activated under hypoxia