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Research involving GHK-Cu has investigated areas including: Extracellular matrix biology Fibroblast activity Collagen-related pathways Cellular signaling Gene-expression-related pathways Matrix remodeling Skin and follicular cellular models Copper-dependent biological processes That makes GHK-Cu particularly interesting when the experimental question involves cellular signaling and extracellular matrix remodeling

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The results showed a significant increase in skin density and thickness, with a 67% reduction in wrinkle volume and improved elasticity, as measured by ultrasound and profilometry (Leyden et al., 2002)