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Dual and Triple Gut Peptide Agonists on the Horizon for the Treatment of Type 2 Diabetes and Obesity. An Overview of Preclinical and Clinical Data | Current Obesity Reports | Springer Nature Link

Tirzepatide acts directly on appetite signalling by activating GLP-1 and GIP receptors, increasing satiety, slowing gastric emptying and enhancing insulin secretion

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In the more common relapsing–remitting form of MS, if an ongoing acute/adaptive immune response were the primary driver of later progression, atrophy and disability, it would stand to reason that there should be a strong correlation between inflammatory relapses and disability throughout the disease course