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L-carnitine — modest, shrinking effect A 2016 meta-analysis of 9 RCTs (n=911) found carnitine users lost about 1.33 kg more than controls, and a larger 2020 meta-analysis of 37 RCTs (n=2,292) found roughly 1.21 kg

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Altered functioning of the glyoxalase enzyme system, with associated accumulation of glycation products, has been shown as another possible pathogenic mechanism in NAFLD (41, 42)