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reported a decreased mucus thickness in the colon of cirrhotic patients and a breakdown of E-cadherin and occludin by endogenous and newly identified bacterial proteases respectively, which could be future therapeutic targets (151)

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However, in the same study, after chronic Mn treatment the rate of Mn increase was higher in the mitochondria of these cells than in the nuclei, with astrocytes sequestering more Mn than neurons (194)