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Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN-mutated patient iPSC-derived dopaminergic neurons

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Despite Nrf1 having a critical function in development, its physiological roles are not yet fully understood, though it does influence uptake of cystine, via the Slc7a11 cystine/glutamate exchange transporter, and lipid metabolism [86, 87] while contributing positively to the basal and in-ducible expression of proteasome subunits [88]

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