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What stood out: CagriSema achieved 23.0% weight loss at 84 weeks (efficacy estimand) Tirzepatide achieved 25.5% On the treatment-regimen estimand, weight loss was 20.2% vs 23.6% Primary endpoint not met: CagriSema did not demonstrate non-inferiority vs tirzepatide on weight loss at 84 weeks Why this matters This is a reminder that in obesity pharmacotherapy, “very effective” and “best-in-class” are not the same conversation

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76 In turn, elevated glutamine consumption by cancer cells diminishes the glutamine supply necessary for T cells, consequently impeding the antitumor immune response