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To achieve this goal there is a need to target both sides of the energy balance equation to reduce energy intake and increase caloric expenditure (113), the effectiveness of the GLP-1R agonist drug class (114) have helped fuel major interest in understanding how the periphery of the body communicates with the brain to suppress appetite (113)

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‍ B Vitamins and Fat Metabolism B Vitamins are directly or indirectly involved in fat metabolism