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The SSG of DJ-1 at Cys106 enhances its mitochondrial localization and ROS scavenging, whereas GRX1 upregulation in MPTP models paradoxically accelerates respiratory chain dysfunction and neuron death (77)

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Critical unresolved issues include identifying the molecular switches that govern the transition of autophagy from an anti- to a pro-ferroptotic state, elucidating subtype-specific differences in crosstalk mechanisms, and clarifying the molecular basis underlying proteins such as COX7A1 to exhibit opposing functions