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Knockout of either Grx5 or Grx3 leads to iron accumulation in cells [31,136,137] , impaired FeS cluster biosynthesis [138] , and deregulated iron homeostasis via IRPs [31,137,139] (Figure 4)

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[DOI] [PubMed] [Google Scholar] 37.Chen L, Petrelli R, Felczak K, Gao G, Bonnac L, Yu JS, Bennett EM, Pankiewicz KW