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Six (17.6%) DPYD carriers who received a standard fluoropyrimidine dose and 58 (7.5%) wild-type patients also treated with a standard dose had severe diarrhea (RR 2.35, 95% CI 0.94–4.81) in the study by Lunenburg et al, 7 whereas six (35.3%) DPYD carriers and 34 (5.8%) wild-type patients had severe diarrhea (RR 6.09, 95% CI 2.37–12.66) in the study by Toffoli et al

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Our reasoning is narrower and we would rather state it plainly: the receptor pathways are complementary, the pharmacology of a bedtime protocol is better described in the literature, and adherence is realistic