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Targeting TET DNA Demethylases With Vitamin C During Somatic Cell Reprogramming The TET proteins (TET1-3) are a sub-family of α-KGDDs that catalyze the hydroxylation of 5-methylcytosine (5mC) residues in DNA to generate 5-hydroxymethylcytosine (5hmC) (Tahiliani et al., 2009), and through successive oxidation reactions, 5-formylcytosine (5fC) and 5-carboxylcytosine (5CaC)